MOTS‑C

1. Product Overview

MOTS‑C (Mitochondrial Open Reading Frame of the 12S rRNA‑C) is a 16‑amino‑acid mitochondrial‑derived signaling peptide, also known as a natural mitokine or mitochondrial hormonePMC. Encoded by mitochondrial 12S rRNA gene, it can translocate from mitochondria to cell nucleus to regulate nuclear gene expression under metabolic stress.

Our MOTS‑C is synthesized and purified under strict biotech standards to form stable white lyophilized powder. It activates AMPK pathways to regulate glucose uptake, fat oxidation and antioxidant defense, serving as a core research material for metabolic disorder, anti‑aging and musculoskeletal mechanism studies. Every batch passes HPLC purity detection and mass spectrometry structural identification, complete Certificate of Analysis, chromatograms and MS spectra are provided for all orders to guarantee stable and repeatable experimental data.

2. Available Specifications

SKU Options:

MS10: 10mg per vial, 10 vials per kit
MS20: 20mg per vial, 10 vials per kit
MS40: 40mg per vial, 10 vials per kit

Custom bulk synthesis and customized single‑vial dosage are available upon customer inquiry for large‑scale cell culture and animal trials.

3. Core Preclinical Research Applications

Insulin Resistance & Obesity Metabolism Research

Boosts skeletal muscle glucose uptake, improves insulin sensitivity and inhibits fat accumulation; widely applied in high‑fat diet induced obesity and type 2 diabetes rodent models.
Mitochondrial Function & Anti‑Aging Studies

Promotes mitochondrial biogenesis, eliminates reactive oxygen species and relieves oxidative stress; used for aging frailty, senescence and longevity exploratory researchnextgenpep….
Skeletal Muscle & Exercise Physiology Research

Enhances exercise endurance, improves muscle energy metabolism and reduces adipose tissue deposition; ideal reagent for sports physiology and muscle anabolism experiments.
Cardiovascular & Vascular Protection Research

Alleviates endothelial dysfunction, suppresses vascular calcification and lowers inflammatory response for cardiovascular injury mechanism studiesnextgenpep….
Bone Metabolism & Anti‑Osteoporosis Research

Stimulates osteoblast collagen synthesis via TGF‑β signaling pathway, suitable for bone loss and osteoporosis preclinical exploration.

4. Strict Quality Control Standards

HPLC purity ≥98%
Mass spectrometry (MS) full structural identity confirmation
Endotoxin level controlled below 0.1 EU/mg
Independent batch COA, HPLC chromatogram and MS spectrum attached
Strict detection of oxidation impurities, residual solvents, heavy metals and moisture

5. Storage & Shipping Guidance

Lyophilized powder storage: Seal tightly, store at -20°C away from light and moisture, shelf life up to 24 months under proper preservationhomopeptid…. Avoid repeated freeze‑thaw cycles to prevent peptide oxidation and activity loss.
After reconstitution: Store at 2–8°C, use within 7–10 days; aliquot into small portions for long‑term repeated use.
Global delivery: Low‑temperature insulated cold‑chain packaging to protect peptide biological activity during cross‑border transportation.
Technical service: Our R&D team supplies reconstitution protocols, storage specifications and experimental scheme consultation within 24 working hours.

6. Important Disclaimer

This lyophilized MOTS‑C peptide powder is for laboratory research use only. It is not approved for human injection, oral administration, clinical treatment or veterinary medication.