KPV

KPV (Lys-Pro-Val) is a synthetic short tripeptide extracted from the C-terminal fragment of α-MSH (alpha-melanocyte stimulating hormone). Our KPV is synthesized and purified under standardized biotech production lines to form stable white lyophilized powder.

This tripeptide retains powerful anti-inflammatory activity of the parent α-MSH, but without pigmentation side effects. It suppresses NF-κB signaling pathway to lower pro-inflammatory cytokines including TNF-α and IL-1β, featuring low endotoxin, high water solubility and stable chemical structure. Every batch passes strict HPLC purity detection and mass spectrometry structural identification, complete Certificate of Analysis, chromatograms and MS spectra are provided for all orders to guarantee repeatable experimental results.

2. Available Specifications

SKU Options:

KPV5: 5mg per vial, 10 vials per kit
KPV10: 10mg per vial, 10 vials per kit

Custom bulk synthesis and customized single-vial dosage can be arranged upon customer demand for large-scale cell and animal trials.

3. Core Preclinical Research Applications

Inflammatory Bowel Disease Research

Relieves intestinal mucosal injury, restores gut barrier integrity and reduces colon inflammation markers; mainstream reagent for DSS/TNBS-induced colitis animal modelsnextgenpep….
Dermatology & Skin Barrier Repair Research

Alleviates contact dermatitis, eczema and psoriasis inflammation, accelerates epidermal wound healing; widely applied in skin anti-inflammation and cosmetic formulation exploratory experiments.
Systemic Immune & Anti-Inflammation Study

Modulates macrophage immune response, relieves systemic inflammatory reaction without broad-spectrum immunosuppression, suitable for peritonitis and organ inflammatory injury research.
Composite Regenerative Peptide Stack Research

Commonly compounded with BPC-157, TB-500 and GHK-CU to develop multi-target repair formulas such as KLOW80 compound peptide kits.
Antimicrobial Mechanism Research

Exhibits mild inhibitory effect against Staphylococcus aureus and Candida albicans for mucosal antibacterial laboratory studiesnextgenpep….

4. Strict Quality Control Standards

HPLC purity ≥99%
Mass spectrometry (MS) full structural identity confirmation
Endotoxin level controlled below 0.1 EU/mg
Independent batch COA, HPLC chromatogram and MS spectrum attached
Comprehensive detection of residual solvents, heavy metals and peptide impurities

5. Storage & Shipping Guidance

Lyophilized powder storage: Seal tightly, store at -20°C, avoid light, high temperature and humid environment, shelf life up to 2-3 years under proper preservation.
After reconstitution: Store at 2–8°C, use within 14 days and avoid repeated freeze-thaw cycles to prevent activity attenuation.
Global delivery: Low-temperature insulated cold-chain packaging protects peptide activity during cross-border transportation.
Technical service: Our R&D team supplies reconstitution protocols, storage specifications and experimental scheme consultation within 24 working hours.

6. Important Disclaimer

This lyophilized tripeptide powder is for laboratory research use only. It is not approved for human injection, oral administration, clinical treatment or veterinary medication.