Tirzepatide

1. Product Overview

Tirzepatide (LY3298176) is a first-in-class synthetic dual agonist targeting both GLP‑1R and GIPR receptors, composed of 39 amino acids with C-terminal long-chain fatty diacid lipid modification for extended half-life. Our Tirzepatide is synthesized and purified via standardized solid-phase peptide synthesis and high-gradient RP-HPLC refinement, presented as uniform white lyophilized powder with excellent water solubility.

Unlike single-target GLP‑1 analogues, this peptide activates two key intestinal hormone pathways simultaneously to suppress appetite, slow gastric emptying and boost insulin secretion in a glucose-dependent manner. It has become the core research reagent for diabetes, weight control and metabolic disorder mechanism exploration. Every batch undergoes strict HPLC purity detection and high-resolution LC-MS full molecular weight verification, complete batch-exclusive Certificate of Analysis, chromatograms and mass spectra are provided to guarantee stable, repeatable experimental results.

Basic Chemical Information:

CAS Number: 2023788‑19‑2
Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈
Molecular Weight: 4813.48 g/mol

2. Available Specifications

SKU Options:

TR5 / RT5: 5mg per vial, 10 vials per kit
TR10 / RT10: 10mg per vial, 10 vials per kit
TR15 / RT15: 15mg per vial, 10 vials per kit
TR20 / RT20: 20mg per vial, 10 vials per kit
TR30 / RT30: 30mg per vial, 10 vials per kit
TR40 / RT40: 40mg per vial, 10 vials per kit
TR50 / RT50: 50mg per vial, 10 vials per kit
TR60 / RT60: 60mg per vial, 10 vials per kit
TR100 / RT100: 100mg per vial, 10 vials per kit

Custom bulk synthesis and customized single-vial dosage are supported for large-scale cell culture and rodent animal trials upon consultation.

3. Core Preclinical Research Applications

Type 2 Diabetes & Glycemic Homeostasis Research

Activates dual incretin receptors to stimulate glucose-dependent insulin release, suppress glucagon secretion and lower HbA1c levels; widely applied in diabetic rodent models for insulin resistance and pancreatic beta-cell protection studies.
Obesity & Body Weight Regulation Mechanism Research

Dual-pathway appetite suppression slows gastric emptying and reduces calorie intake; ideal reagent for visceral fat breakdown, BMI control and adipocyte metabolism exploratory experiments.
Combined Compound GLP-1 Research

Commonly compounded with Cagrilintide to develop dual-target metabolic formulas (CS5 / CS10), and matched with Retatrutide for triple receptor agonist comparative research (RTT60 compound stack).
Non-Alcoholic Fatty Liver Disease (NAFLD) Studies

Reduces hepatic lipid accumulation and improves liver insulin sensitivity for fatty liver metabolic pathway research.
Cardiovascular Metabolic Protection Research

Lowers blood lipid levels and alleviates vascular endothelial inflammatory injury for cardiometabolic disorder mechanism exploration.

4. Strict Quality Control Standards

HPLC purity ≥99% via reverse-phase gradient chromatography
High-resolution LC-MS intact molecular weight identity confirmation
Endotoxin level strictly controlled below 0.1 EU/mg
Independent batch COA, HPLC chromatogram and full MS spectrum attached
Comprehensive detection of truncated peptide impurities, lipidation byproducts, residual solvents and heavy metals
Stability testing under ICH standard acid, oxidative, thermal and photolytic stress conditionsPMC

5. Storage & Shipping Guidance

Lyophilized powder storage: Seal tightly, store at -20°C, fully avoid light, high temperature and humid environment; shelf life reaches 24 months under proper sealed preservation.
After reconstitution: Store at 2–8°C, aliquot into small portions to avoid repeated freeze-thaw cycles which cause lipid modification degradation and activity loss.
Global delivery: Low-temperature insulated cold-chain packaging maintains peptide biological activity during cross-border long-distance transportation.
Technical service: Our professional R&D team supplies reconstitution protocols, storage specifications and experimental scheme consultation within 24 working hours.

6. Important Disclaimer

This lyophilized Tirzepatide peptide powder is for laboratory research use only. It is not approved for human injection, oral administration, clinical treatment or veterinary medication. All test data and product descriptions are limited to academic laboratory exploratory research purposes.